NUR 550 Topic 1 DQ 2 Select a population health problem or issue of interest from the available studies

NUR 550 Topic 1 DQ 2 Select a population health problem or issue of interest from the available studies

Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research. Select a population health problem or issue of interest from the available studies. What type of translational research is used for the study? Provide rationale as to why this is the best.

Re: Topic 1 DQ 2

When looking through the GCU library for an interesting study containing translational research, I found this study called “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” (Harischandra et. Al, 2020). This study states that there are treatment options out there for those patients with Parkinsons, like deep brain stimulation and medications like levodopa, but these treatments are only touching the surface of the issue at hand (Harischandra et. al, 2020). They state that for future (better) treatment for these patients they need to look at the dopaminergic neurons as well as the dopamine transporter (Harischandra, et. Al, 2020). They attempted to preform studies on rats but found that the cells differed in a way that would not give them accurate results (Harishchandra, et. Al, 2020). They then went on to utilize embryonic stem cells and developing these into LUHMES cells which more closely resembled the pathways they were trying to achieve (Harischandra, et. Al, 2020). By doing their experiments on these cells they are in the T1 transition, pre patient and practice, in the lab studying the real effects on the neural pathways (Translational Research, n.d.). I’m not going to lie the study is lengthy and the process they utilized involved a ton of chemicals and days of watching these cells develop into what they needed, but at the end of 5 days their processes had drastically increased the reuptake of dopamine in the cells (Hasichandra, et. Al, 2020). Stem Cells are not always available for drug research so being able to develop these LUHMES cells to test on is great for the future of Parkinson’s research and for testing drugs (Harischandra et. Al, 2020).

 

Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165533. 

Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). . Retrieved June 18, 2021, from 

 

RESPOND HERE (150 WORDS, 2 REFERENCES)

This is insightful, Sarah, the study, “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” Contains translational research expressed in different ways. The study highlighted indicates different methods or options for managing or treating Parkinson’s (Harischandra et al., 2020). The article further elaborates that the approaches applied only touch on the surface of the issue that has been identified. From the research study highlighted, there is the application of T1 translational research. The approach that has been used has proved critical when it comes to the determination of the outcomes of the research process. From the study highlighted, it has been found that Parkinson’s is a disease or disorder that greatly impacts the functioning of the brain. The conditions often lead to stiffness, shaking, and difficulty with body balance, walking, as well as general coordination (Rubio et al., 2019). The study highlighted that the symptoms of Parkinson’s diseases normally start and progress gradually and worsen over time. As the disease progresses, there is always difficulty in talking and walking.

References

Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165533. 

Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., … & Bermejo-Martín, J. F. (2019). Current gaps in sepsis immunology: new opportunities for translational research. The Lancet Infectious Diseases, 19(12), e422-e436.

Re: Topic 1 DQ 2

Incidences of stroke in the U.S. have declined in the past few years for the first time in history. However, stroke incidence among older adults has always been higher than younger adults, especially older women (Portz et al., 2018). Older adults of 80 years and above make about 17% of all stroke patients and are at high risk of mortality and prolonged hospital stays (Portz et al., 2018). This journal is in phase T4 type of translational research, where the information obtained in the previous stages is disseminated and implemented. This translational research aimed to investigate the impact of physical fitness and exercises for older adults with chronic stroke. A large body of literature has examined the correlation between self-management intervention such as physical fitness and exercise and chronic stroke. For instance, Schmid et al. (2014) observed that patients with chronic stroke showed physical improvements like body balance after enrolling in a yoga program that involved physical activities such as walking.

Based on the previous literature, Portz et al. (2018) used the information to investigate whether physical fitness and exercise would be used as a clinical intervention for managing chronic stroke. After implementing the information, Portz et al. (2018) found that it is essential for health care professionals to incorporate self-management interventions such as physical fitness and exercise in managing chronic stroke among older adults. This will improve their quality of life, strength, and endurance by incorporating yoga practice. Furthermore, this kind of research will encourage more health care researchers to conduct translational research to reach phase 4 (T4), where yoga practice can be used as an evidence-based intervention for chronic stroke.

 

References

Portz, J. D., Waddington, E., Atler, K. E., Van Puymbroeck, M., & Schmid, A. A. (2018). Self-management and yoga for older adults with chronic stroke: A mixed-methods study of physical fitness and physical activity. Clinical Gerontologist, 41(4), 374–381. https://doi-org.lopes.idm.oclc.org/10.1080/07317115.2016.1252453

Schmid, A. A., Miller, K. K., Van Puymbroeck, M., & DeBaun-Sprague, E. (2014). Yoga leads to multiple physical improvements after stroke, a pilot study. Complementary Therapies in Medicine, 22(6), 994–1000. https://doiorg.lopes.idm.oclc.org10.1016/j.ctim.2014.09.005

 

RESPOND HERE (150 WORDS, 2 REFERENCES)

 

This is insightful Listra; stroke has been a major concern in the United States. However, over the last previous years, the incidences of stroke in the U.S. have declined. However, stroke incidence among older adults has always been higher than among younger adults, especially older women. Stroke is attributed to different factors, including overweight and unhealthy eating (Kamin et al., 2020). The translational research and the methodology that has been applied greatly provide insight into the incidences of stroke and the approaches that can be undertaken to enhance the significant reduction in the incidences of stroke in the entire United States of America. The type of translational research applied in the study identified is T4. The information acquired or obtained from the previous stages of research has been disseminated and implemented in the research process (Portz et al., 2018). Self-management interventions are critical in the management of cases of stroke. Some of the self-management procedures may include adherence to physical activities as well as measures that may reduce the cases of obesity.

Important information for writing discussion questions and participation

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I understand this is a lot of information to cover in 5 weeks, however, the Bible says in Philippians 4:13 that we can do all things through Christ that strengthens us. Even in times like this, we are encouraged by God’s word that we have that ability in us to succeed with His strength. I pray that each and every one of you receives strength for this course and life generally as we navigate through this pandemic that is shaking our world today. Relax and enjoy the course!

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Important information on Writing a Discussion Question

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• Include in-text citations in your response
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• Follow APA-7th edition
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